Lysozyme Visualization and Analysis by Usine Various Bioinformatics Tools

Abstract

Th~ detailed molecular diagrams and illustrations available in some of the c~ccllent biodu:mistl") textbooks curr~ntly available can he accessible to anyone ''ith intcmet capability through the use of molecular information and good visualisat ion and manipulation sotlware packages which arc freely available over the web. Individual students can uti lise the \'isualisation programmes to investigate the 30 structure of proteins. zoom in on the active site of enzymes. observe groups at the active site or im ol~cd in binding or look at the molecular dimensions between groups on a protein. Primar) data on 30 structure of proteins are available at the protein data bank (POB). the single international repository for the processing and distribution of 3D macromolecular structure data, mostly obtained by X-ray crystallography or solution nuclear magnetic resonance (NMR). The empirical results of these experimental methods accuratel} describe the 3D structure of a protein molecule in the state in \\hich measurements were made. To illustrate the modelling capabilities ofav:ulable programmes data on the 30 structure ofthe enzyme lysozyme will be used.